Although the species grows in a variety of habitats, they are often associated with coniferous forests. This is due to mycorrhizal relationships with conifers, a mutualistic relationship in which both organisms benefit. Like most polypores, the terrestrial Albatrellus confluens is a wood decomposer. This fungus typically grows gregariously, but will sometimes either occur as scattered individuals or tightly clumped in fused groupings. The fruiting cap is pale peach in colour, and circular with a diameter of 3-20 cm. It is also characterized by cream-coloured pores on the underside surface. Supporting the cap is a thick white stipe or stalk. As the mushroom ages, it may become green with algae and develop irregular cracks.
Grifolin is a natural substance that can be isolated from the edible flesh of Albatrellus confluens. In one study, the effects of grifolin on human osteosarcoma cells (osteosarcoma is the most common type of bone cancer) was investigated. The study concluded that grifolin inhibited rapid proliferation (multiplying) of the cell population (by suppressing the signalling pathways of mitochondria in the cancer cells) and induced apoptosis (cell death). However, the impact from grifolin was found to be dependent on its concentration and time of exposure. Grifolin continues to be studied for potential use in cancer treatment.